Developmental and reproductive performance in circadian mutant mice
نویسندگان
چکیده
منابع مشابه
Developmental and reproductive performance in circadian mutant mice.
BACKGROUND Genes underlying circadian rhythm generation are expressed in many tissues. We explore a role for circadian rhythms in the timing and efficacy of mouse reproduction and development using a genetic approach. METHODS We compare fecundity in Clock(Delta19) mutant mice (a dominant-negative protein essential for circadian rhythm activity) and in Vipr2-/- null mutant mice (affecting the ...
متن کاملObesity and metabolic syndrome in circadian Clock mutant mice.
The CLOCK transcription factor is a key component of the molecular circadian clock within pacemaker neurons of the hypothalamic suprachiasmatic nucleus. We found that homozygous Clock mutant mice have a greatly attenuated diurnal feeding rhythm, are hyperphagic and obese, and develop a metabolic syndrome of hyperleptinemia, hyperlipidemia, hepatic steatosis, hyperglycemia, and hypoinsulinemia. ...
متن کاملEndurance training ameliorates the metabolic and performance characteristics of circadian Clock mutant mice.
Circadian locomotor output cycles kaput (CLOCK) is a nuclear transcription factor that is a component of the central autoregulatory feedback loop that governs the generation of biological rhythms. Homozygous Clock mutant mice contain a truncated CLOCK(Δ19) protein within somatic cells, subsequently causing an impaired ability to rhythmically transactivate circadian genes. The present study soug...
متن کاملLoss of circadian rhythmicity in aging mPer1-/-mCry2-/- mutant mice.
The mPer1, mPer2, mCry1, and mCry2 genes play a central role in the molecular mechanism driving the central pacemaker of the mammalian circadian clock, located in the suprachiasmatic nuclei (SCN) of the hypothalamus. In vitro studies suggest a close interaction of all mPER and mCRY proteins. We investigated mPER and mCRY interactions in vivo by generating different combinations of mPer/mCry dou...
متن کاملIncreased Anxiety in Offspring Reared by Circadian Clock Mutant Mice
The maternal care that offspring receive from their mothers early in life influences the offspring's development of emotional behavior in adulthood. Here we found that offspring reared by circadian clock-impaired mice show elevated anxiety-related behavior. Clock mutant mice harboring a mutation in Clock, a key component of the molecular circadian clock, display altered daily patterns of nursin...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2005
ISSN: 1460-2350,0268-1161
DOI: 10.1093/humrep/dei313